Zhe-Sheng Chen Selected Research

sipholenol A

4/2015	Esters of the marine-derived triterpene sipholenol A reverse P-GP-mediated drug resistance.
11/2010	Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells.
9/2007	Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells.

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Zhe-Sheng Chen Research Topics

Disease

206	Neoplasms (Cancer) 10/2022 - 02/2003
22	Breast Neoplasms (Breast Cancer) 01/2022 - 04/2007
16	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/2022 - 10/2010
12	Neoplasm Metastasis (Metastasis) 09/2022 - 11/2008
11	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 12/2014
10	Lung Neoplasms (Lung Cancer) 11/2022 - 05/2015
9	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2021 - 07/2009
8	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2022 - 04/2007
7	Carcinoma (Carcinomatosis) 11/2022 - 07/2002
7	Colonic Neoplasms (Colon Cancer) 09/2021 - 09/2014
6	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 03/2009
6	Leukemia 01/2021 - 02/2012
5	COVID-19 01/2022 - 09/2020
5	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 11/2013
5	Hematologic Neoplasms (Hematological Malignancy) 02/2020 - 05/2015
4	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 05/2015
4	Cardiotoxicity 01/2022 - 01/2017
4	Ovarian Neoplasms (Ovarian Cancer) 01/2021 - 01/2013
3	Carcinogenesis 01/2022 - 04/2011
3	Infections 01/2022 - 01/2020
3	Triple Negative Breast Neoplasms 12/2021 - 11/2019
3	Adenocarcinoma 01/2021 - 11/2017
3	Acute Promyelocytic Leukemia 01/2021 - 09/2007
3	Melanoma (Melanoma, Malignant) 04/2019 - 03/2016
2	Pancreatic Neoplasms (Pancreatic Cancer) 10/2022 - 05/2021
2	Adenocarcinoma of Lung 10/2022 - 01/2021
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 07/2022 - 06/2022
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 06/2022 - 01/2021
2	Disease Progression 05/2022 - 01/2021
2	Multiple Myeloma 03/2022 - 01/2020
2	Stomach Neoplasms (Stomach Cancer) 01/2022 - 10/2010
2	Pain (Aches) 01/2022 - 01/2022
2	Fibrosis (Cirrhosis) 01/2022 - 01/2022

Drug/Important Bio-Agent (IBA)

64	Pharmaceutical PreparationsIBA 10/2022 - 11/2002
50	ATP-Binding Cassette Transporters (ABC Transporters)IBA 10/2022 - 11/2007
44	Adenosine Triphosphate (ATP)IBA 01/2022 - 02/2003
40	Proteins (Proteins, Gene)FDA Link 11/2022 - 11/2002
27	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2022 - 04/2007
25	Paclitaxel (Taxol)FDA LinkGeneric 12/2021 - 09/2007
17	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2022 - 04/2007
17	Antineoplastic Agents (Antineoplastics)IBA 01/2022 - 10/2009
12	Tyrosine Kinase InhibitorsIBA 10/2022 - 11/2007
11	ErbB Receptors (EGF Receptor)IBA 10/2022 - 11/2007
10	Mitoxantrone (Novantrone)FDA LinkGeneric 09/2021 - 11/2007
9	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 07/2002
9	Phosphotransferases (Kinase)IBA 01/2021 - 02/2012
8	Biological ProductsIBA 09/2022 - 12/2012
8	multidrug resistance-associated protein 1IBA 09/2017 - 10/2010
7	Biomarkers (Surrogate Marker)IBA 09/2022 - 06/2014
7	Topotecan (Hycamtin)FDA LinkGeneric 05/2022 - 06/2014
6	Member 2 Subfamily G ATP Binding Cassette TransporterIBA 05/2022 - 01/2021
6	Irinotecan (Camptosar)FDA LinkGeneric 09/2021 - 09/2012
6	Imatinib Mesylate (Gleevec)FDA Link 01/2021 - 07/2009
6	TriterpenesIBA 04/2015 - 06/2007
4	Circular RNAIBA 01/2022 - 11/2019
4	Messenger RNA (mRNA)IBA 01/2022 - 12/2014
4	MicroRNAs (MicroRNA)IBA 01/2022 - 01/2020
4	CytokinesIBA 01/2021 - 10/2012
4	oridoninIBA 01/2020 - 07/2014
3	Gefitinib (Iressa)FDA Link 10/2022 - 11/2007
3	Cytotoxins (Cytolysins)IBA 05/2022 - 09/2007
3	EnzymesIBA 04/2022 - 11/2018
3	Docetaxel (Taxotere)FDA Link 01/2022 - 04/2007
3	Adenosine Triphosphatases (ATPase)IBA 01/2022 - 11/2019
3	N-methyladenosineIBA 01/2022 - 12/2020
3	RNA (Ribonucleic Acid)IBA 05/2021 - 10/2020
3	Arsenic Trioxide (Trisenox)FDA Link 01/2021 - 09/2007
3	AlkaloidsIBA 01/2021 - 06/2014
3	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2021 - 11/2007
3	Subfamily B ATP Binding Cassette TransporterIBA 01/2021 - 09/2011
3	Oncogene Proteins (Oncogene Protein)IBA 01/2021 - 04/2016
3	Vincristine (Oncovin)FDA LinkGeneric 01/2021 - 04/2007
3	Colchicine FDA LinkGeneric 01/2020 - 09/2007
3	bcr-abl Fusion ProteinsIBA 01/2020 - 07/2009
3	ibrutinibIBA 01/2020 - 12/2014
3	SurvivinIBA 04/2019 - 04/2007
3	regorafenibIBA 01/2019 - 01/2017
3	Tyrosine (L-Tyrosine)FDA Link 11/2017 - 02/2012
3	Lapatinib (GW572016)FDA Link 01/2017 - 10/2008
3	sipholenol AIBA 04/2015 - 09/2007
3	Vinblastine (Vinblastine Sulfate)FDA Link 05/2013 - 09/2007
3	nilotinib FDA Link 01/2013 - 07/2009
3	Phosphodiesterase 5 InhibitorsIBA 08/2012 - 04/2011
2	LipidsIBA 11/2022 - 02/2020
2	Proteolysis Targeting ChimeraIBA 11/2022 - 01/2021
2	osimertinibIBA 10/2022 - 09/2016
2	Sorafenib (BAY 43-9006)FDA Link 09/2022 - 01/2022
2	tepotinibIBA 05/2022 - 01/2019
2	Proteasome InhibitorsIBA 03/2022 - 01/2020
2	6-methyladenineIBA 01/2022 - 12/2020
2	OTS964IBA 01/2022 - 01/2021
2	Therapeutic UsesIBA 01/2022 - 01/2021
2	VaccinesIBA 01/2022 - 01/2021
2	ProteomeIBA 01/2022 - 11/2008
2	MTOR InhibitorsIBA 01/2022 - 10/2019
2	Digoxin (Digitek)FDA LinkGeneric 01/2022 - 12/2020

Therapy/Procedure

68	Drug Therapy (Chemotherapy) 10/2022 - 04/2007
54	Therapeutics 09/2022 - 11/2007
4	Immunotherapy 05/2022 - 11/2018
3	Radiotherapy 01/2022 - 04/2018